Tag: 上海千花网

Barcoding Antarctic biodiversity: current status and the CAML initiative, a case study of marine invertebrates.

The Census of Antarctic Marine Life (CAML) aims to collate DNA barcode data for Antarctic marine species. DNA barcoding is a technique that uses a short gene sequence from a standardised region of the genome as a diagnostic ‘biomarker’ for species. This study aimed to quantify genetic data currently available in GenBank in order to establish whether a representative cross-section of Antarctic marine taxa and bio-geographic areas has been sequenced and to propose priorities for barcoding, with a particular emphasis on marine invertebrate species. It was found that, amongst marine invertebrate fauna, sequence information covers a limited range of taxa and areas-mainly Crustacea, Annelida and Mollusca from the Weddell Sea and the Antarctic Peninsula. Only 15% of genes sequenced in Antarctic marine invertebrates were the standard barcode gene cytochrome c oxidase subunit 1 (CO1), the majority were other nuclear and mitochondrial genes. There is an urgent need for more in-depth genetic barcoding and species identification studies in Antarctic science, from a range of taxa and areas, given the rate of climate-driven habitat changes that might lead to extinctions in the region. CAML hopes to redress the balance, by collecting and sequencing over the circum-Antarctic area, using material from voyages that occurred during 2008 and 2009, within the framework of the International Polar Year (IPY). read more

Closing the gap

first_imgMortality rates after cancer surgery declined for Black as well as white patients during a recent 10-year period, although the mortality gap between the two groups did not narrow, according to new research by Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Harvard University investigators.The findings, published online today by JAMA Network Open, present a mixed picture for health care policymakers: While postsurgical mortality rates have fallen for patients generally, more targeted efforts are needed to reduce disparities between Black and white patients undergoing such surgery, study authors say.“Black Americans are likely to be diagnosed with more advanced cancer than whites and, historically, have had higher mortality rates following cancer surgery,” said lead author Miranda Lam of Dana-Farber, Brigham and Women’s Hospital, Harvard T.H. Chan School of Public Health, and Harvard Medical School. “Hospitals have put a variety of policies in place to improve surgical cancer care over the past 15 years. This study provided an opportunity to gauge the effects of those measures for patients in general and for Black and white [people] specifically.”Investigators used national Medicare data to examine the trends in mortality rates for the years 2007-2016 in Black and white patients who had undergone surgery for any of nine major types of cancer. (The racial group was determined by patients’ self-identification in Medicare documentation.) The data covered 870,929 cancer operations in all.The researchers found that national mortality trends following cancer surgery improved for Black and white patients by 0.12 percent and 0.14 percent per year, respectively. Because mortality rates for Black patients were higher to begin with than for white patients, the equal decline in rates for both groups meant the gap between them did not shrink.“The findings tell us that even though policies designed to improve cancer surgery outcomes are working better for all patients, none of them have been specific enough to close the gap in mortality between Black and white [people],” Lam said. “It’s possible that part of the gap may be due to upstream and/or downstream issues from the surgery itself, such as late referrals which may lead to late presentation at time of surgery, fragmented follow-up after discharge, and limited resources in the community, and that different policies and interventions may be needed to address disparities in cancer surgery.”The senior author of the study is Jose F. Figueroa of Harvard T.H. Chan School of Public Health, Brigham and Women’s, and Harvard Medical School. Co-authors are Katherine Raphael and Jessica Phelan of Harvard T.H. Chan School of Public Health; and Winta T. Mehtsun, E. John Orav, and Ashish K. Jha of Harvard T.H. Chan School of Public Health, Brigham and Women’s, and Harvard Medical School.last_img read more

Semenya says she is ‘unquestionably a woman’

first_imgFILE PHOTO: Caster SemenyaJohannesburg, South Africa | AFP | South African 800m Olympic champion Caster Semenya on Thursday said she was “unquestionably a woman”, after the IAAF denied reports that it would argue that she should be classified as a biological male.Semenya, 28, issued the statement ahead of a landmark hearing at the Court of Arbitration (CAS) next week that will challenge a proposed rule by the International Athletics Federation (IAAF) aiming to restrict testosterone levels in female runners.“Ms Semenya is unquestionably a woman. She is a heroine and an inspiration to many around the world,” her lawyers said in a statement.“She asks that she be respected and treated as any other athlete.”The rules would force so-called “hyperandrogenic” athletes or those with “differences of sexual development” (DSD) to keep testosterone levels below a prescribed amount.The rules were to have been instituted in November 2018 but have been put on ice pending next week’s hearings.Supported by the South African Athletics Federation, the two-time Olympic champion in the 800m (2012, 2016) and three-time world champion (2009, 2011, 2017) has denounced the proposals. “I just want to run naturally, the way I was born. It is not fair that I am told I must change. It is not fair that people question who I am,” she has said previously.“She looks forward to responding to the IAAF at the upcoming CAS hearing,” Semenya’s legal team said, adding that “her genetic gift should be celebrated, not discriminated against”.As well as Semenya, the silver and bronze medallists of the 800m at the Rio Olympics, Francine Niyonsaba of Burundi and Kenya’s Margaret Wambui, have also faced questions about their testosterone levels.“The IAAF is not classifying any DSD athlete as male,” the IAAF said in a statement. “To preserve fair competition in the female category, it is necessary to require DSD athletes to reduce their testosterone down to female levels.”A CAS spokesman confirmed to AFP on Thursday that the hearing is scheduled for next week in Lausanne from Monday to Friday with Semenya in attendance.Share on: WhatsApplast_img read more

Learn the The Art of Hollywood Storytelling

first_imgPolish your script and learn the secrets of Hollywood storytelling from three professional story consultants.I recently stumbled onto this vast archive of interviews with filmmakers who work in positions that you don’t often get access to. There are interviews (broken up into handily titled sections) with storyboard artists, script consultants, production managers, focus pullers, compositors, and many more. Unfortunately for me, as a non-Swedish speaker, most of the interviews are in the participants native language, which I believe is Swedish!That said, I’ve pulled out this trio of interviews with three professional story consultants and script doctors, all speaking in English, who have great insight to share on improving your storytelling and filmmaking abilities.Script and Story ConsultantsChris Soth, Michael Hauge and Linda Seger are all story consultants. This means they’ve been called in to help filmmakers like Will Smith on I Am Legend, Hancock, and The Karate Kid, or Ron Howard on (apparently) every one of his movies since Apollo 13, to help restructure the film and ensure the character arcs and motivations are working as well as they can.“Story is the most important thing, everything comes after. and if you’re serious about being a filmmaker, and that means being serious about being a storyteller you have to understand structure.” – Chris SothLinda Segar’s bestselling book How to Make a Good Script Great, is personally endorsed by Ron Howard, and after working on over 2000 scripts and a 30+ year career, she certainly knows her stuff. In this video, Linda shares her thoughts on the best way to make it as a writer, which sadly, involves no short cuts.Writers write. you need to get writing and you need to get a number of scripts written. Rarely do you sell your first script. Sometimes in the US people say you need to write at least five scripts, and spend at least five years learning the craft. And then maybe, you’ll sell it, or get an agent or have something happen with it… it’s learning the art in yourself and bringing that out and learning the craft.Michael Hauge, who can be found on Story Mastery.com, shares some elementary advice for the things writers need to do to write their first script well.One of the things I recommend that writers do, that sometimes are either too obvious, or writers don’t think of it. Number one, you gotta read screenplays. I encouter a lot of people who hire me to consultant on their screenplay and pay a lot of money to do that, and I’ll say ‘Well how many scripts have you read.’ and they’ll say ‘Well, I’ve read three.’ And it’s like, you can’t possibly master a craft when you’ve only seen three examples of it being done.A fantastic resource for script writers (that gives you over four hundred examples of different ways of approaching screenwriting elements) is the Mentorless series of script breakdowns, How Did They Write That. Essentially you can see how the writer achieved various things from introducing a character, or writing an action scene, or a phone call, or a description of a character and much more.It’s a brilliant way to quickly see how numerous professional screenwriters approach the task in their own style.The Art of the StoryboardAs an added bonus, there is also this extended interview with storyboard artist Giuseppe Cristiano on how he approaches his storyboard art work and craft. In this first video you get a tour of the tools Cristiano likes to work with and pick up this handy tip…You’ll notice that I use a red pencil [for the initial sketch], and that’s something that you use in animation, so that you can do your clean up in pen, and scan them in you can remove the red pencil [digitally].You can check out more of Cristiano’s storyboards on his site.What resources do you use for pre-production? Share in the comments below.last_img read more

Dawson Creek wins BC SPCA Award

first_imgDAWSON CREEK, B.C. — The City of Dawson Creek was awarded with the BC SPCA’s Humane Community Award at the society’s annual awards ceremony in Richmond on May 4th. The award was presented by the SPCA in recognition of the city’s approach to humane welfare for animals. BC SPCA CEO Craig Daniell said that in 2015, the city introduced an animal responsibility bylaw designed to address cat overpopulation by encouraging spay/neuter and permanent identification.“It takes a strong community effort to address the suffering of animals, and the mayor and council of Dawson Creek have shown outstanding leadership in working with the BC SPCA and other partners to create a better life for animals in their region,” said Daniell. “The city’s mandatory cat licensing bylaw has also made a significant impact. In 2017 nearly 800 cats were licensed – more than the number of dogs licensed that same year – which has enabled the BC SPCA’s South Peace Branch to increase the return rate of lost cats to their guardians from 10 to 40 per cent.”Licensing fees are $5 for a fixed cat and $200 for an unfixed cat. Thanks to the generous support of PetSmart Charities™ of Canada, the South Peace SPCA has been able to provide free spay and neuter surgeries to the city’s residents. The grant program led to a significant increase in bylaw compliance. In 2015, 73 percent of kittens coming into the care of the South Peace Branch came from the city of Dawson Creek. This number decreased to 31 percent last year. All of the 2018 BC SPCA Award winners. Supplied photo.“The leadership demonstrated by the city of Dawson Creek has made a life-saving difference for animals in their community and is a model for other communities across B.C.,” added Daniell.last_img read more

Fort Nelson expected to see summertime snow this weekend

first_imgMeanwhile, Fort St. John and the Peace is expected to receive a significant amount of rain this weekend and into Monday. For Saturday, we could see anyway between 5 to 10 mm, with the same expected for Sunday and Monday.If you plan on travelling this weekend, be sure to check DriveBC.ca for up-to-date travel information and road conditions. FORT ST. JOHN, B.C. – Higher elevations in Northern British Columbia, such as the Fort Nelson area, could receive snow over the weekend.According to Environment Canada Meteorologist, Doug Lundquist, Fort Nelson and surrounding area could receive a light dusting of snow this weekend.The snow is expected to start sometime late afternoon on Saturday and wrapping up early Monday morning as the temperature is expected to rise once again to more seasonal levels.last_img read more

Will be tough to comeback if we lose 4-5 matches in a row: Stokes

first_imgChennai: Rajasthan Royals all-rounder Ben Stokes has said that his team can’t afford to lose another game after suffering three consecutive defeats in the IPL. Stokes said there was no point in looking back and focus on the upcoming games because if they lose the next two, bouncing back could be beyond Royals’ reach. “Our first three games we got ourselves into a real good position to win All three, and we know it is just (about) winning those crucial moments. (This game) it was the last over and unfortunately we couldn’t cross the line,” Stokes said at the post-match press conference after the eight-run loss against Chennai Super Kings here on Sunday night. Also Read – Puducherry on top after 8-wkt win over Chandigarh”There is always been one point in the three games were we haven’t been a better team. Losing the first three games you probably would say we can’t (take positives), but we are trying to and there is no point in looking back…Because if we lose 4-5, it’s going to be really tough to come back from that,” he said. Stokes also hailed CSK captain Mahendra Singh Dhoni saying there was a lot to learn from him. Dhoni smashed an unbeaten 75 to bail his team out of trouble from 27 Also Read – Vijender’s next fight on Nov 22, opponent to be announced laterfor three. “Hindsight is a wonderful thing, if you look back at it like that. He just takes it deep as he possibly can. He’s a great person to learn from and watch how he goes about his innings whether it’s setting a total or chasing a total. “Sometimes you got to hold your hand up and say the best players in the world can do that. He certainly showed that tonight.” Paying tribute to Dhoni’s finishing skills, the Englishman said he is one of the greatest finishers to have graced the game and the Royals tried to attack him but he got reprieves which could have been a turning point. “Especially when he comes in early, every team knows what he’s going to try and do to start with and we tried to attack him. Getting him out was our main objective. There was a dropped catch which you can’t blame anyone for – that happens – and the ball hitting the stumps and the bails not coming off.” The Royals needed 12 runs in the final over to seal win but failed to do as the experienced Dwayne Bravo yet again kept things tight and took the wicket of Stokes. About this, the Royals player said the first ball is crucial and Bravo knew what to do. “And probably though the first ball is crucial to get a boundary (in the last over), and to try and get the momentum, you know (it) could have gone (for a boundary) but (Dwanye) Bravo is sort of experienced in those situations and he knows what to do and he is one of the best in the world doing it, so just say well bowled at the end of the day.” Stokes said there was a little bit of pace in the wicket but it was ‘stoppy’ and the dew made it hard for the bowlers. “(There was) little bit pace and (it was) stoppy, towards the end the quicker ball couldn’t not lay easier and in the end the dew helped (the ball) to come on nicely. “The dew on the top of the grass was making the ball slippery and you could see how many times the ball was changed and it was a tough task for us, imagine how hard it was for the spinners considering they used their fingers to spin the ball,” he added.last_img read more

Palestinian mourners clash with Israeli forces in W. Bank

first_imgRAMALLAH – Thousands of Palestinians held a massive funeral for Mahmoud Awad, 22, who breathed his last on Thursday of injuries he sustained last year during clashes with Israeli forcesViolent clashes erupted between Palestinian mourners and Israeli forces in the West Bank following the funeral procession of a young man, who died of injuries he sustained one year ago.Thousands of Palestinians held a massive funeral for Mahmoud Awad, 22, who breathed his last on Thursday of injuries he sustained last year during clashes with Israeli forces.Eyewitnesses said mourners hurled stones at Israeli forces near the Qalandia checkpoint between Ramallah and Al-Quds (occupied Jerusalem). Israeli forces used teargas and rubber bullets to disperse the angry Palestinians.Awad was pronounced dead in a Ramallah hospital where he lied in a coma after he sustained a gunshot injury in the head a year ago.last_img read more

Baseballs Hot Stove Has Gone From Cold To Basically Turned Off

“We’ll closely monitor developments,” an MLB Players Association spokesperson said to FiveThirtyEight last month. “If 30 clubs are competing for a pennant, the free-agent market for players will be robust.”But fewer teams seem interested in competing.The Seattle Mariners and Arizona Diamondbacks, 2018 contenders, are retooling. The American League Central champion Cleveland Indians have shed payroll in a weak division they can likely win without spending on free agents.And teams seem to have learned, collectively, to wait out free agents. Thirty-five free agents signed guaranteed major league deals last year between Feb. 1 and opening day,2Excluding players who signed with one team earlier in the offseason, were released and signed with another team within the February-to-April period. compared with 18 in 2017, 13 in 2016, 10 in 2015 and 13 in 2014. The longer free agents wait, the fewer dollars they’re typically awarded.Even the star free agents are having to wait.Consider that in the not-so-distant past, top players had usually signed by now. Just look at the contracts inked before Christmases past: On Dec. 1, 2015, David Price signed the richest deal ever for a starting pitcher (seven years and $217 million) with the Boston Red Sox, and he was followed three days later by Zack Greinke, who signed a six-year, $206.5 million deal with Arizona. On Dec. 10 of the previous year, Jon Lester signed a $155 million deal with the Chicago Cubs. And in 2013, Robinson Cano signed a 10-year, $240 million deal with the Seattle Mariners on Dec. 6, just three days after Jacoby Ellsbury signed a seven-year, $153 million deal with the Yankees.But the five richest contracts of last offseason were awarded after Jan. 24. And only one contract so far this offseason has topped $100 millionThere are other factors behind the slow down, said Chaim Bloom, vice president of baseball operations for the Tampa Bay Rays. His club reportedly signed pitcher Charlie Morton on Dec.12.“I’m hesitant to call something a trend before having [enough] information to really say this is a new normal — it might just be a slight shift in the timetable,” Bloom said to FiveThirtyEight last week. “There is a lot more information available. Teams increasingly like to have more and more information before making decisions. That may push some things later in the calendar. I also think — and this offseason is a good example of it — staff movement and staff [hirings] are taking up a larger chunk of offseason. … The more coaching staffs and front offices grow, the more time that is going to take [in early offseason].”Have teams learned to wait out the market?“I don’t know if it’s ideal for clubs, necessarily,” Bloom said of the slower markes. “You want to go into spring training knowing who you have.”Free agency has become more and more a battleground between teams and players. Clubs are accused of suppressing the service time of potential stars so as to control their prime years at cheaper salaries. Teams also seem to be wary of allocating a large share of their payroll to one player. Alex Rodriguez’s $275 million deal with the Yankees — signed Dec. 13, 2007 — remains the record for a free-agent contract even as MLB revenues have increased from $6 billion in 2007 to exceeding $10 billion in 2017.Regardless of whether free-agent superstars Harper and Manny Machado set contract records, they are expected to receive guaranteed dollars well into nine figures. The greater concern for the union is what another slow-to-develop market means for the middle class of free agents — which represents the vast majority of players.A slow-to-develop market forced unsigned players to create their own spring training camp last year in Bradenton, Florida. David Freese knows this trend well. After the former World Series MVP finished the 2015 season with 2.2 wins above replacement, he sought a lucrative, multiple-year contract. But he had to settle in March for a one-year, $3 million deal with the Pirates.“It was a tough situation to handle,” Freese said in 2016. “The waiting, it challenges your heart. Sitting around while guys are out playing [in spring training] … seeing games, seeing guys in the field.”Rather than test free agency this winter after the Dodgers were likely to turn down his $6 million club option, he re-signed with the club on a one-year, $4.5 million deal.Freese isn’t the only player to take that approach. Josh Donaldson — the 2015 A.L. MVP — agreed to a one-year, $23 million deal with Atlanta on Nov. 26. He was joined by 18 other free agents signing contracts for just one year, making up 67.9 percent of the 28 signings so far through Monday. That’s the greatest share of one-year contracts signed through the first 50 days of the offseason over the past six winters. (The next closest was 52 percent in 2016-17.)Some of these players may have decided to bet on themselves on shorter-term deals in the hopes of maximizing their future earning potential. Or perhaps they are responding to seeing players with hopes of signing lucrative multi-year deals last offseason, like Mike Moustakas and Neil Walker, languish on the market until spring training had started.Free agents across the game appear to be in store for another longer wait. Perhaps this is the new normal.Sara Ziegler contributed research. LAS VEGAS — The Mandalay Bay Hotel and Casino was, in some ways, the most appropriate host for baseball’s winter meetings: After all, this offseason was once expected to be punctuated by announcements of record-setting, high-dollar free-agency deals. Bryce Harper, a premier free agent, is a Las Vegas native. But away from the din of the casino floor, a podium set up for press conferences in a vast ballroom was largely quiet last week. After last winter marked the slowest signing period in at least the previous 18 years, this offseason is starting even more slowly, according to a FiveThirtyEight analysis of free-agent data.Teams already seemed less interested in giving time on the field to players over the age of 30 — the time frame in which many players first become eligible for free agency. But now, early in the offseason, teams also seem increasingly less willing to spend on any free agent.Consider that through Monday, 50 days after the World Series concluded, only 5.2 percent of available free-agent players1Our pool of available free agents includes any player with major league experience who was granted free agency or released in October and November of each season. That excludes players signed internationally or those waived by a club before the season ended or later in the offseason. had signed major league deals for guaranteed money, according to a FiveThirtyEight analysis of data from The Baseball Cube. Fifty days after the end of the 2017 World Series, 5.5 percent of available free agents had signed. Two years ago that number was 9.2 percent. In the three offseasons prior to that winter — 2015-16, 2014-15 and 2013-14 — it was 9.2, 7.8 and 10.9 percent respectively.Through Monday, $442.5 million had been spent on free agents. That’s down from $469.8 million at the same point last year, which was down from $976.5 million in the winter of 2016-17, $1.401 billion in 2015-16, $1.173 billion in 2014-15 and $1.229 billion through the middle of December 2013. read more

Womens gymnastics No 19 Ohio State snags win in final rotation against

Ohio State junior Taylor Harrison preforms on balance beam in St. John Arena on Feb. 18 with her teammates watching from the side. Credit: Megan Russell | Lantern reporterAfter closely trailing the Mountaineers before entering the final rotation, the Ohio State women’s gymnastics team sealed a victory with strong performances on floor against West Virginia on Saturday.The Buckeyes posted a 49.200 on floor to tally a final score of 196.075-195.800 over West Virginia. “Our last three kids on floor are dynamite, and so I knew they were going to have to go a 9.800 or better to win the meet,” OSU coach Carey Fagan said. “You could tell — once that momentum started building deeper in our lineup — it was going to be really hard for West Virginia to stay with us.”In the first rotation on vault, junior Alexis Mattern scored a team-high 9.900 to take first overall in the event. Mattern also posted her second 9.900 of the night on floor.“This is actually the first time I’ve ever done that in my career,” Mattern said. “I may not have had the highest overall scores I’ve ever had, but consistency wise, it was one of my more consistent nights, so I’m happy with it.” In the second rotation on the uneven bars, Mattern also scored a career-high of 9.875 to take first in the event while sophomore Kaitlyn Hofland posted a 9.850 to finish in second. Senior Tenille Funches also earned a season-high of 9.825 on uneven bars.Olivia Aepli had two false starts before completing her routine on bars for the team-low of 8.750.“Olivia normally goes 9.900 on bars, and that’s the type of performance we need,” Fagan said. “Not everybody on the team has 9.900 potential, but the ones that do have that 9.900 potential, they have to come through. So little things like that can be frustrating.” At the midpoint of the meet, OSU led the Mountaineers by a meager .025.On balance beam, junior Stefanie Merkle started the lineup for OSU, posting a 9.775 to tie for third in the event with freshman Amanda Huang. Junior Taylor Harrison took first in the event with a strong score for the team of 9.875 and to tie her season-high.“Normally, going in, being last on beam — even when somebody falls or the scores are low — I try not to let that mess with my head,” Harrison said. “I just know that when I get up there, I do what I do every single day in the gym. So today, going into that routine, I felt very confident.”Heading into the final rotation, the Buckeyes trailed West Virginia 146.875-146.775.The final three performers for the floor event propelled the OSU team to set them up for the win. Those included Harrison who posted a career-high of 9.875 to take third in the event behind Mattern’s 9.900, while Merkle scored a close 9.850 behind Harrison. “I think the highlight for me was probably the last three floor routines because they knew and they could feel that the meet was on the line,” Fagan said. “And so, for them to come out and really hit really solid routines, I think it will build their confidence, and it builds the team’s confidence too.”Mattern placed first in the all-around with a 39.375. read more

Recent Comments